https://www.saviochanlab.org/overview daily 1.0 2026-09-03 https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499146535081-AS2W2XHG76A4HF2DJ3HJ/5A0A0478.JPG About https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499431545947-EY3XAUEXYDIXZN6D27UC/Screen+Shot+2017-07-07+at+7.43.46+AM.png About https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499743956540-4A1205I90LP4QXUKNJFD/5A0A0208.JPG About https://www.saviochanlab.org/team daily 0.75 2026-09-04 https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499652937266-V5V3IHXA9IS1B96CBV6Y/5A0A0724.JPG Team https://www.saviochanlab.org/pi-index daily 0.75 2026-09-06 https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/73f96a7b-dad5-463a-b870-dcf16d6dd13a/5A0A0239.jpg.webp PI Index https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/fce03781-b367-4ab7-be10-55abf2b6a106/5A0A0239.jpg.webp PI Index https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/ed171eaf-bd12-41b5-a51d-d3431cc160fe/5A0A0239.jpg.webp PI Index https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/ccf33730-9407-45f4-a4ad-804c0f3af68c/Savio+portrait.png PI Index https://www.saviochanlab.org/contact daily 0.75 2026-09-08 https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499653611481-MCZSPVAEYC57U6VSJVGX/5A0A0456.JPG Contact https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499266714313-5L7BRBSI5N7QZ4Q83ITQ/image-asset.jpeg Contact https://www.saviochanlab.org/approaches daily 0.75 2022-07-31 https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499433674193-CFA4L69H2EIG1III130K/Screen+Shot+2017-07-03+at+10.51.52+PM.png Approaches https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1520596933817-6G9F3OVU7PUKVXGPTUJS/Screen+Shot+2018-03-08+at+10.45.01+PM.png Approaches https://www.saviochanlab.org/join daily 0.75 2026-09-07 https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1513326427662-MY02IKJ8JL7D9YH9AWZP/5A0A7868.jpg Join https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499265225744-F5CX7TEWTYRHC7633WL4/image-asset.jpeg Join https://www.saviochanlab.org/publications daily 0.75 2026-09-01 https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/1499143402211-AD3C43DVIJJXIU4ZG6XW/5A0A0397.JPG Publications https://images.squarespace-cdn.com/content/v1/595b0d1403596e64bf61645b/a2c852fb-cf2f-4a7a-a01e-08f9c4959cdb/Screenshot+2026-09-01+at+5.55.24%E2%80%AFPM.png Publications - Make it stand out Multilayer Framework and Outstanding Questions in GPe Taxonomy. Hierarchical framework organizing open questions in GPe taxonomy across three interconnected biological scales, linked by curvy arrows that denote cross-scale, bi-directional flow. The Model System panel depicts the mouse as the primary experimental substrate for this framework, reflecting extensive genomic and neuroanatomical conservation with humans alongside the transgenic and spatial-mapping infrastructure that makes cell-type-resolved circuit manipulation tractable at scale. 01. Molecular Specification & State Plasticity (Micro-scale): Focuses on disentangling immutable identity features from context-dependent state variables, and microenvironmental factors that shape cell fate across development and disease. 02. Biophysical & Circuit-Level Organization (Meso-scale): Addresses synaptic dynamics and microcircuit architecture, including differential neuromodulation (DA, ACh, neuropeptides), dedicated versus collateralized projection pathways, and the specific biophysical mechanisms by which defined cell types execute movement. 03. 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